ABC News recently listed 6 Airline Travel Myths, including whether opening a door mid-flight can be done and what happens when your luggage is mishandled.
"There are a couple of reasons for this, but the big one is cabin pressure which, in effect, seals the doors shut. Plus many aircraft doors are "plug-type" in design meaning the doors are bigger than the opening (unless they are rotated). Again, though, once cabins begin to pressurize, which occurs as the plane begins to taxi, well - forget it. Those doors are shut."